Preheat the oven to 350 degrees F (175 degrees C).
2
Bring a large pot of lightly salted water to a boil. Add lasagna noodles and cook for 10 minutes or until al dente; drain.
3
Meanwhile, place ground beef, garlic, oregano, garlic powder, salt, and black pepper in a large skillet over medium heat; cook and stir until beef is crumbly and evenly browned, about 10 minutes.